Reduced PKCα expression in pulmonary arterioles of broilerchickens is associated with early feed restriction
The present study was conducted to investigate the effect of early feedrestriction on protein kinase Cα(PKCα) expression in pulmonary arterioles,which has been revealedto promote pulmonary vascular remodeling in pulmonary hypertensive broilers.Methods: A total of 270 day-old mixedsex commercial broilers were randomly distributed to a normaltemperature Control group(NT),a low temperature Control group(LT) and a low temperature plus feedrestriction group(LR). The PHS incidence,the right/total ventricular weight ratio(RV/TV),the vesselwall area/vessel total area ratio(WA/TA),the mean media thickness in pulmonary arterioles(mMTPA)and the expression of PKCα in the pulmonary arterioles were measured weekly. Results: Lowtemperature treatment significantly increased the PHS mortality. The RV/TV,WA/TA and mMTPAvalues of group LT were significantly elevated Compared with those of group NT on d 35 and 42. TheLT chickens had increased PKCα expression Compared with their NT Counterparts on d 28 andafterwards. Feed restriction reduced the PHS mortality,RV/TV,WA/TA and mMTPA incold-exposed broilers. The LR chickens had much lower PKCα expression in pulmonary arterioiesthan the LT chickens.Conclusion: Early time feed restriction inhibited pulmonary vascular remodelingin broilers,which might be partly attributed to reduced PKCα expression in pulmonary arterioles.
肉鸡 肺动脉高压 肺小动脉 饲料营养 体重
Jia-qiang Pan Xun Tan Jin-chun Li Wei-dong Sun Guo-qing Huang Xiao-long Wang
Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls,Nanjing Agricultural Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls,Nanjing Agricultural
国内会议
广州
英文
650-659
2008-11-01（万方平台首次上网日期，不代表论文的发表时间）