Possible role of nitric oxide in the pathogenesis of pulmonary hypertension in broilers: a synopsis
Nitric oxide(NO) produced by vascular endothelial cells is an important determinantof the basal tone of small arteries and arterioles. Impaired endothelial NO production has beenimplicated in the pathophysiology of pulmonary hypertension(PH) in humans. Available data suggestthat reduction of endothelial NO synthesis,with evidence of reduced endothelial NO synthase(eNOS)expression in pulmonary arterioles,is associated with increased pulmonary vasomotor tone andvascular remodelling in hypertensive broilers. Supplemental L-arginine,a precursor of NO,has beenshown to induce flow-dependent pulmonary vasodilation,to prevent reduced eNOS expression and,toinhibit vascular remodelling in broilers with PH. Nevertheless,its effect on pulmonary hypertensionsyndrome(PHS) incidence is limited. It appears that impaired NO is a secondary rather than acausative factor in the pathogenesis of PH in broilers.
肉鸡 肺动脉高压 发病机制 一氧化氮
Xun Tan Xiao-Long Wang
Department of Veterinary Medicine,Zhejiang University,Hangzhou 310029,P. R. China Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls,Nanjing Agricultural
国内会议
广州
英文
641-649
2008-11-01（万方平台首次上网日期，不代表论文的发表时间）