Adiponectin Expression Murine Model of Sepsis
Sepsis constitutes a significant consumption and remains an ever-present problem in the hospital．It has been estimated that about 400,000 to 500,000 patients are so affected eachyearin both the USA and Europe．Morbidity and mortality have remained highdespiteim provements in both supportive andanti-microbial therapies．Sepsis is defined clinical as the systemicinflammatory response of the host to thedocumentedsystemic infection．Pro-inflammatory andanti-inflammatory mediators secreted by a range of immune cells are thought to play a crucial rolein inducing the inflammatory responses documentedand outcome of sepsis．In this context，multiplelines of evidence have suggested that adipokinesare important contributors to the pathophysiologyof sepsiS．In particular，there weresubstantial increases in the expressions ofvarious pro-inflammatory substances such as TNF-α，IL-6. MCP-1 and a significant decrease in theanti-inflammatory substances such as adiponectinin chronic inflammatory disorders e.g.obesityand diabetic．
鲍红光
江苏南京市第一医院麻醉科
国内会议
黄山
英文
166-174
2007-06-01（万方平台首次上网日期，不代表论文的发表时间）