Overexpression of Cyclooxygenase-2 is Associated with Chemoradiotherapy Resistance and Prognosis in Esophageal Squamous Cell Carcinoma Patients
Previous investigations have shown that elevated COX-2 expression is associated withresistance to treatment and reduced overall survival for patients who received neoadjuvant chemo- orradiotherapy. Experimental models have demonstrated that selective COX-2 inhibitors canenhance the efficacy of radiotherapy or chemotherapy. In this context, COX-2 expression maypredict sensitivity to chemoradiotherapy (CRT), and also may be a target for sensitization inEsophageal squamous cell carcinoma (ESCC). However there are only several small-sample studieson the relationship between COX-2 expression and response of ESCC to chemoradiotherapy.The aim of our study was to assess the expression of COX-2 by immunohistochemistry inpatients with esophageal squamous cell carcinomas. The analysis was done in patients whounderwent definitive or neoadjuvant chemoradiotherapy, and the results were correlated withresponse to chemoradiotherapy and overall survival.
W.-Z.Huang J.Wen T.-H.Rong J.-H.Fu M.-Z.Liu Y. Hu H.Yang Y.-F.Feng B.Zheng G.Wang K.-J.Luo
State Key Laboratory of Oncology in Southern China,Guangzhou,China Department of Thoracic Surgery,Ca State Key Laboratory of Oncology in Southern China,Guangzhou,China Department of radiology,Cancer Ce State Key Laboratory of Oncology in Southern China,Guangzhou, China State Key Laboratory of Oncology in Southern China,Guangzhou,China Department of Thoracic Surgery,Ca
国内会议
广州
英文
128-133
2008-05-16（万方平台首次上网日期，不代表论文的发表时间）