Increased supperssive activity of CD4+CD25+ regulatory T cells on CD4+ T cells from Persistent HCV-infected Patients could be reversed by high concentration of interlukine 2
HCV infection is characterized by chronic immune activation and increasing array of immune dysfunetions”Gerlach et al, 1999; Nascimbeni et al, 2003”.An early and persistent Thl一dominated CD4 response, whichis critical in the prevention of the chronically infected state ”Lechner et al, 2000”，is particularly impaired, anddefects appear during a chronic course in disease ”Rosen, et al, 2002; Ulsenheimer, et al, 2003”.The basis ofHCV一specific CD4+T cell immune dysfunction has not been fully elucidated. In this regard, one avenue thathas not been explained fully in relation to HCV一specific immune responses is the potential role of host一mediatedimmunosuppressive mechanisms that might be activated in the face of persistent antigenic exposure.
regulatory interlukine HCV-infected
Jianghua Yang Lei He Jiaqing Zhao Yongxiang Zhang Chuan Su Nanxiong Sun
Department of Infectious Diseases, Affiliated Yijishan Hospital of Wannan Medical College, Wuhu Department of Pathogen Biology, Jiangsu Province Laboratory of Pathogen Biology, Naning Medical Univ Department of Infectious Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing
国内会议
安徽黄山
英文
203-208
2007-05-01（万方平台首次上网日期，不代表论文的发表时间）