THE UTILITY OF <”18>F-FDG PET/CT FOR DETECTION OF POST-OPERATIVE RECURRENCE IN ESOPHAGEAL CANCER
The purpose of the current study is to evaluate the clinical value of <”18>F- fluorodeoxyglucose PET/CT on detecting post-operative recurrence in patients with esophageal cancer. Methods 37 post-operative patients with esophageal cancer underwent PET/CT scans from June 2003 through August 2005 to detect recurrent disease; a final diagnosis was reached by the histopathology or clinical follow-up of at least 6 months. The diagnostic sensitivity, specificity, and accuracy ofPET/CT were assessed at local, regional and distant sites, as well as overall estimate for a composite of all the above sites. The false-positive and false- negative results of PET/CT were analyzed as well. Results 31 out of 37 patients were finally confirmed with recurrence in a total of 46 sites. There were six false-positive findings in PET/CT reportsinvolving two sites at esophagogastric anastomosis, one near the back wall of gastric pull-up, two at hilar lymph nodes, and one in left lower lung. There were three false-negative PET/CT interpretations including one subcarina lymph node, one paratracheal lymph node and one metastatic lesion in the right lower lung. The overall sensitivity, specificity andaccuracy of PET/CT for detecting recurrence were 93.5％(43/46), 76.9％(20/26) and 87.5％ (63/72), respectively. On a site-based analysis, it was found that only the specificity at local sites was lower (50％) because of a high rate of false-positivefindings (3 cases in 6). In contrast, PET/CT had excellent performance both at regional and distant sites, the sensitivity, specificity and accuracy were 86.7％, 84.6％ and 85.7％ for regional recurrence, versus 95.5％, 85.7％ and 93.1％ for distant metastasis, respectively. Conclusion <”18>F-FDG PET/CT is highly effective in detecting regional and distant recurrence for post-operative patients with esophageal cancer. However the specificity was rather low at local area due to a high rate of positive findings, particularly at anastomosis, endoscopy is essential to reach a final diagnosis in this instance.
PET/CT esophageal cancer recurrence
Hongbo Guo Baijing Zhang Limin Zhang Wanlong Li Xibin Liu li Ma Yong Huang Jinming Yu
Department of Thoracic Surgery, Shandong Cancer Hospital & Institute, Jinan 2501147, Shandong Provin Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, Shandong Provi Department of Nuclear Medicine, Shandong Cancer Hospital & Institute, Jinan 250117, Shandong Provinc Department of Radiology, Shandong Cancer Hospital & Institute, Jinan 250117, Shandong Province, P.R.
国内会议
北京
英文
156-164
2007-10-19（万方平台首次上网日期，不代表论文的发表时间）