Mannose prevents lipopolysaccharide-induced acute lung injury in rats

摘要：

Throughout the development of glycobiology，some polysaccharides such as those found in cordyceps sinensis，cryptoporus polysaccharide，and Cyanobacteria，have been found to have anti-inflammatory properties. Interestingly，the common component of these polysaccharides is mannose.Mannose is a simple hexose sugar with a molecular weight of 180.2，and it has been found to have anti-inflammatory effects.Mannose treatment inhibits the inflammatory reaction in wound healing and decreases leukocytes，especially neutrophils，in wound fluid. Mannose also inhibits the neutrophil oxidative burst，which plays an important role in inflammation. Mannose-6-phosphate，the mannose derivative，has been shown to inhibit adjuvant arthritis and have anti-inflammatory activity in wound healing.

作者: Xuanli Xu Qiangmin Xie Yihong Shen Jingjin Jiang Yuanyuan Chen Hongyi Yao Jianying Zhou

作者单位: Department of Respiratory Medicine,First Affiliated Hospital,Medical College of Zhejiang University, Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration, Medical Colleg

会议类型: 国内会议

会议名称: 2007年(第二十九届)浙江省医学会呼吸病学学术年会

会议地点: 浙江湖州

会议语种:英文

在线出版日期: 2007-06-01（万方平台首次上网日期，不代表论文的发表时间）