会议专题

多壁碳纳米管反义核酸复合体的静电组装及其在细胞内的传递

Telomerase activity has been found in ~85-90% ofall human tumors but not in adjacent normal cells.This makes telomerase a target not only for cancerdiagnosis but also for the development of novel genetherapeutic agents. Among nucleic acid-based methodsfor controlling gene expression,antisense(AS)therapies are potentially powerful candidates forclinical treatments of various ailments,includingcancer. In conventional AS approaches,antisenseoligodeoxynucleotides(ASODNs)designed to hybridizewith target mRNA sequences down regulate theexpression of the corresponding translated proteins.Although ASODNs have emerged as an exciting andpromising strategy in the field of cancer therapy inrecent years,their development in viable therapeuticsystems has faced challenges due to theirsusceptibility to enzyme degradation and poorintracellular uptake. Therefore,suitable drugdelivery systems are needed to develop foreffectively improving cellular uptake and stabilityof ASODNs.

多壁碳纳米管 反义核酸复合体 静电组装 细胞内传递

贾能勤 连琼 沈鹤柏

上海师范大学生命与环境科学学院化学系,上海 200234

国内会议

第十四次全国电化学会议

扬州

中文

948-949

2007-11-02(万方平台首次上网日期,不代表论文的发表时间)