Bacillus subtilis improves immunity and disease resistance in rabbits
Probiotics such as Lactobacillus and Bifidobacterium have been successfully used to promote growth and prevent diseases.Previous reports have demonstrated that Bacillus subtilis(B.subtilis)was a potential probiotic for animals.In this research,180 B.subtilis were isolated from the soil,identified and investigated in vitro.Furthermore,five B.subtilis were selected and mixed to investigate their effect on growth performance,immune response,intestine microbiota and disease resistance in rabbits.Rabbits with a diet of 106 CFU g-1 mixed B.subtilis exhibited the best growth performance,and higher serum IgG and IgA than controls(P < 0.05).Moreover,dairy with B.subtilis can promote the balance of intestinal flora.The major pro-inflammatory factor and β-defensin were up-regulated compared with the controls.After 7 weeks of feeding,the survival rate of the rabbits fed with B.subtilis was significantly higher than those in the control groups post-infected with Escherichia coli.At the same time,this study detected higher expression of β-defensin and reduced bacteria contents of the heart and cecal contents from the diet mixed with B.subtilis compared with the control groups.In conclusion,dietary supplementation with B.subtilis for rabbits could improve growth performance,intestinal homeostasis and immune organ index,and enhance innate immune response as well as disease resistance.These findings showed that the induction of β-defensin by B.subtilis might be an interesting new therapeutic strategy to strengthen innate defence mechanisms.
probiotics Bacillus subtilis growth performance innate immunity disease resistance
Mengjiao Guo Fahao Wu Guangen Hao Qin Qi Rong Li Ning Li Liangmeng Wei Tongjie Chai
College of Veterinary Medicine,Shandong Agricultural University,Sino-German Cooperative Research Cen College of Veterinary Medicine,Shandong Agricultural University,Sino-German Cooperative Research Cen Taian City Central Hospital,Tai'an City,Shandong Province,China,271000
国内会议
成都
英文
5-17
2019-05-29（万方平台首次上网日期，不代表论文的发表时间）