A Novel and Compact Review on the Role of Oxidative Stress in Female Reproduction
In recent years,the study of oxidative stress(OS)has become increasingly popular.In particular,the role of OS on female fertility is very important and has been focused on closely.The occurrence of OS is due to the excessive production of reactive oxygen species(ROS).ROS are a double-edged sword; they not only play an important role as secondary messengers in many intracellular signaling cascades,but they also exert indispensable effects on pathological processes involving the female reproduction tract.ROS and antioxidants join in the regulation of reproduction processes in both animals and humans.Imbalances between pro-oxidants and antioxidants could lead to a number of female reproduction diseases.This review focuses on the mechanism of OS and a series of female reproduction processes,explaining the role of OS in female reproduction and female reproduction diseases caused by OS,including polycystic ovary syndrome(PCOS),endometriosis,preeclampsia and so on.Many signaling pathways involved in female reproduction,including the Keap1-Nrf2,NF-κB,FOXO and MAPK pathways,which are affected by OS,are described,providing new ideas for the mechanism of reproduction diseases.
ROS oxidative stress reproduction diseases antioxidants imbalance female fertility signaling pathways
Jiayin Lu Zixu Wang Jing Cao Yaoxing Chen Yulan Dong
Laboratory of Neurobiology,College of Animal Medicine,China Agricultural University,Beijing Haidian 100193,People's Republic of China
国内会议
成都
英文
63-79
2019-05-29（万方平台首次上网日期，不代表论文的发表时间）