蜂毒治疗慢性下腰痛的临床对照研究
The rheumatic diseases express the largest palette of pain,both under pain physiopathologic mechanisms and the pain intensity level.Among these,the chronic low back pain(CLBP)represents a major health problem having high social impact,characterized by important costs and economics losses,but also an important suffering source in individual plan.Aim:The health policy coordinators from many countries have included complementary therapies(as acupuncture and bee venom therapy)among the recommended treatment procedures in CLBP.However the results of complementary treatments are still controversial,especially in the case of the western population.The aim of this paper is to validate or invalidate the use of bee venom therapy and acupuncture in CLBP by means a comparative study with one of the most usual pharmaceutical treatments,the one with Diclofenac.Material and methods:A prospective case-control study including 220 patients has been performed.The patients have been divided in 5 groups,first treated with diclofenac(55 patients),second treated with acupuncture(52 patients),third treated with bee venom(28 patients),fourth treated with a combination of acupuncture and bee venom(53 patients)and the fifth treated with a combination of diclofenac and bee venom therapy(31 patients).The pain intensity estimation was performed using the visual analogical scale(VAS)and the pain sensitivity was measured with a numeric algometer.The results were statistically processed and analyzed,the signification threshold being p=0.05.Rezults:The differences between treatment results for the different groups became statistic significant(p<0,05)only after six days of treatment.All the applied treatments were benefic,but surprisingly,the better results came from the combination of diclofenac with the bee venom therapy.Positive potentiation of the two therapies in the combination may result from the intervention of bee venom through a mechanism of inhibition of a step in the prostaglandin synthesis cascade.An important advantage of this therapeutic combination is the reduction of the dose of diclofenac and thereby the reduction of adverse effects specific to long-term treatments.Conclusions:The present study has some limits(it is cohort type and not randomized,done over a quite long period of 18 months),but proves for the first time that the association of diclofenac and bee venom therapy can be one of the most effective therapies with minimal adverse effects between therapies used in chronic lumbar pain.
Chronic low back pain Bee venom therapy Diclofenac Acupuncture
Beatrice Lucache
国内会议
首届世界蜂疗大会,世界中联蜂疗专业委员会第二届学术年会、中国民族医药学会蜂疗分会2018年学术年会
深圳
中文
73-74
2018-11-09（万方平台首次上网日期，不代表论文的发表时间）