Oral tranexamic acid can reduce blood loss after total knee and hip arthroplasty:A meta-analysis
Objective:The aim of the present study was to compare the efficacy and safety of oral tranexamic acid(TXA)with controls or intravenous TXA in patients undergoing total joint arthroplasty(TJA)in a systematic review and meta-analysis.Methods:We systematically searched randomized controlled trials(RCTs)from PubMed,Embase,the Cochrane Central Register of Controlled Trials(CENTRAL),Web of Science and Google databases.Any studiescomparingoralTXAversusacontrolgrouporintravenousTXAforpatientspreparedforTJAwere included.The outcomes included the need for transfusion,hemoglobin drops,length of hospital stay and drain volume.We calculated the risk ratio(RR)with a 95%confidence interval(CI)for the need of transfusion and the weighted mean difference(WMD)with a 95%CI for hemoglobin drop,length of hospitalstayanddrainbloodloss.Statal2.0 wasusedforthemeta-analysis.Results:Five clinical trials(5 RCTs)involving 333 patients were finally included in this meta-analysis.When compared with the control group,oral TXA was associated with less need for transfusion,fewer hemoglobin drops,less drain volume and a shorter length of hospital stay(P<0.05).When compared withⅣTXA,oral TXA was associated with more hemoglobin drops(P<0.05).However,there was no significant difference between the need for transfusion,drain volume and the length of hospital stay between oral TXA andⅣTXA.Conclusion:Oral TXA has comparable hemostatic effects withⅣTXA and may reduce the costs for patients prepared for TJA.However,considering the limited quality and number of the included studies,more high-quality and multi-center RCTs are still needed to recommend oral TXA for routine administration.
Tranexamic acid Total joint arthroplasty Oral Blood loss Meta-analysis
Li Guang-lei Li Yong-mei
Department of Orthopedic,Linzi District People's Hospital,Zibo,Shandong,255400 Clinical Laboratory Linzi District People's Hospital,Zibo,Shandong,255400
国内会议
武汉
英文
224-237
2018-01-01（万方平台首次上网日期，不代表论文的发表时间）