Traditional Chinese Medicine integrated with chemotherapy for stage Ⅱ-ⅢA patients with non-small cell lung cancer after radical surgery:a retrospective clinical analysis with small sample size
Objective:This study was designed to evaluate the clinical efficacy of combined traditional Chinese medicine(TCM)and conventional chemotherapy versus conventional chemotherapy only in patients with stage Ⅱ-ⅢA non-small cell lung cancer(NSCLC)after radical surgery.Methods:A retrospective cohort study was conducted in patients with stageⅡ-ⅢA NSCLC from Subei People's Hospital and Yangzhou Traditional Chinese Medicine Hospital in Yangzhou City of Jiangsu Province from 2012 to 2016.Patients were divided into TCM user group(receiving treatment with integrated TCM and conventional chemotherapy)and non-TCM user group(receiving conventional chemotherapy only).The main outcomes included the median disease-free survival(DFS)and median overall survival(OS).Results:A total of 67 patients with stage Ⅱ-ⅢA NSCLC receiving TCM or non-TCM treatment were enrolled between January,2012 and December,2016.The median DFS for the non-TCM user group was 601 days(95%confidence interval[C],375.7-826.3).Though the median DFS for TCM user group could not be calculated,the log-rank analysis showed that the median survival time in the TCM user group was significantly longer than that of the non-TCM user group(P<0.05).In addition,some significant risk factors were detected for predicting disease prognosis in patients with NSCLC,such as age,ECOG,lymphatic metastasis and body mass index(BMI).For patients harboring these independent risk factors,the DFS of TCM user group was much longer than that of non-TCM user group(P<0.05).Conclusion:Adjuvant therapy with TCM may reduce the rate of tumor recurrence and metastasis,and prolong DFS of patients with stage Ⅱ-ⅢA NSCLC.
Xueyu Zhao Xiaojun Dai Shanshan Wang Ting Yang Yan Yan Guang Zhu Jun Feng Bo Pan Masataka Sunagawa Xiaochun Zhang Yayun Qian Yanqing Liu
Department of combine traditional Chinese and western medicine,Yangzhou University School of Medicin Department of combine traditional Chinese and western medicine,Yangzhou University School of Medicin Clinical Traditional Chinese Medical College,Yangzhou University,Yangzhou,Jiangsu 225000,China Department of combine traditional Chinese and western medicine,Yangzhou University School of Medicin Department of Physiology,School of Medicine,Showa University,Tokyo 142,Japan
国内会议
兰州
英文
235-248
2018-08-01（万方平台首次上网日期，不代表论文的发表时间）