IN VITRO AND IN VIVO IMMUNE STIMULATING EFFECTS OF A POLYSACCHARIDE FROM POTENTILLA ANSERINA ROOT (JUE MA)

摘要：

Potentilla Anserina polysaccharide (PAP) was studied to investigate its stimulating effects in vitro or in vivo. The in vitro investigation demonstrated that PAP enhanced splenocyte proliferation and was associated with an increase in NO production. The in vivo investigation demonstrated that intraperitoneal administration of PAP was able to overcome cyclophosphamide-induced immunosuppression and siginificantly raised glutathione level, thymus and spleen indices, and decreased malondialdehyde level in a dose-dependent manner in mice. The results demonstrate that PAP might play an important role in modulation of an immunological system which will lead to the exploration for PAP as a strong potential immunostimulant in food and pharmaceutical fields.

关键词： Potentilla anserina polysaccharide Splenocyte proliferation Nitric oxide Glutathione Malondialdehyde Cyclophosphamide

作者: Jiongran Chen Zhiqiang Yang Tingjun Hu Zuoting Yan Tingxian Niu Ling Wang Dongan Cui Meng Wang

会议类型: 国际会议

会议名称: The ist International Conference on Traditional Chinese Veterinary Medicine,The 12th Chi Institute Annual Conference(首届中兽医药学国际学术研讨会)

会议地点: 兰州

会议语种:英文

页码: 19-28

在线出版日期: 2010-09-13（万方平台首次上网日期，不代表论文的发表时间）