Endothelial nitric oxide synthase gene polymorphisms and the risk of ischemic stroke in young Chinese population
Genetic influences are important in multifactorial ischemic stroke and may act via endothelial dysfunction. Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) is a key mediator of endothelial function. We determined the role of 3 potentially functional eNOS polymorphisms (T-786C, intron 4ab, G894T) located toward the 5 flanking end of the gene as risk factors for ischemic stroke in young Chinese population. 100 patients with ischemic stroke and 100 controls were studied. Genotypes were determined through polymerase chain reaction with or without restriction fragment digestion. The intron 4a variant was protective against ischemic stroke in young Chinese population.
eNOS SNP ischemic stroke young Chinese population
Congning Shi Yajie Wang Yali Zhou Xixiong Kang
Department of experimental and diagnosis center, Beijing Tiantan Hospital, the fifth affiliated hospital of Capital Medical University, Beijing, China,100050
国际会议
The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)
苏州
英文
2007-09-10（万方平台首次上网日期，不代表论文的发表时间）