The therapeutic effect and mechanism of human bone marrow mesenchymal stem cells transplantation in MRL/lpr mice

摘要：

To investigate the therapeutic effects and mechanism of human bone marrow mesenchymal stem cells(MSC) transplantation in MRL/lpr mice. Human MSCs were expanded ex vivo. MRL/lpr mice were divided into cyclophosphamide (CTX) group, MSC group, CTX+MSC group, and control group. At the age of 16 weeks, the mice in CTX group and MSC+CTX group received intraperitoneal injection of CTX 100mg/kg×2d. 24 hours after injection, the MSCs were transplanted in MSC group and CTX+MSC group through tail vein. Human MSC transplantation is effective treatment for MRL/lpr mice. The regulation of Th1/Th2 balance and inhibition the antibodies of B cells mediated by human MSCs may be the mechanisms of effective treatment.

关键词： lupus erythematosus, systemic mesenchymal stem sells transplantation

作者: Kang-Xing Zhou Ou-Yang Jin Xue-Bing Feng Ya-Yi Hou Ling-Yun Sun

作者单位: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital, Nanjing University Me Immunology Laboratory, Nanjing University Medical School, Nanjing, China

会议类型: 国际会议

会议名称: The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)

会议地点: 苏州

会议语种:英文

在线出版日期: 2007-09-10（万方平台首次上网日期，不代表论文的发表时间）