Docking study of HIV-1 integrase tetramer with different length segments of viral end DNA
HIV-1 integrase (IN) is an essential enzyme for viral replication cycle and a widely held assumption is that functional IN acts as a tetramer. The association of the IN tetramer with eight different length segments of viral end DNA were investigated by using DOT package.Based on the eight bindings, the DNA binding regions of IN tetramer and the influence of the length of viral DNA to the association were explored.The results indicate that there are three DNA binding regions of IN tetramer for viral DNA. Further, two regions are the viral DNA binding regions, and the rest are the host DNA binding region.All of the above simulation results agree well with experimental data, which provide us a more complete structural basis for guiding drug discovery and reveling integration mechanism.
HIV-1 IN tetramer molecular docking drug discovery
Guo-Tao Ke Jian-Ping Hu Wei-Zu Chen Cun-Xin Wang
College of Life Science and Bioengineering, Beijing University of Technology, Beijing, China, 100022 College of Life Science and Bioengineering, Beijing University of Technology, Beijing, China, 100022
国际会议
The 5th International Forum on Post-genome Technologies(5IFPT)(第五届国际后基因组生命科学技术学术论坛)
苏州
英文
2007-09-10（万方平台首次上网日期，不代表论文的发表时间）