Temperature-sensitive star-shaped block copolymers hydrogels for an injection application: Phase transition behavior and biocompatibility
A series of star-shaped poly(D,L-lactic-co-glycolic acid)-b-methoxy poly(ethylene glycol) (PLGA-mPEG) block copolymers with varying PLGA/mPEG block weight ratios, mPEG block length, and arm numbers were synthesized and phase transition behaviors were investigated.Phase transition characteristics, such as critical gel concentration (CGC) and critical gel temperature (CGT), were closely related to the molecular structure of the star-shaped block copolymers.The CGC was mainly determined by the balance of hydrophobic PLGA and hydrophilic mPEG block(PLGA/mPEG block ratio).The CGTs showed a stronger dependence on mPEG block length and arm number.Also, the CGTs can be adjusted by adding mPEG homopolymer additives.The weight fraction ofmPEG had a stronger influence on the CGT values than molecular weight of mPEG.In addition, the MTT assay and histological observations confirmed the acceptable biocompatibility of the star-shaped block copolymer.Hence,the star-shaped PLGA-mPEG block copolymer was a promising candidate as a novel injectable gel.
Lei Nie Peng Zou Jinping Suo Ruixia Hou Jun Fu
Polymers and Composites Division, Ningbo Institute of Materials Technology & Engineering,Chinese Aca State Key Laboratory of Mould Technology, College of Materials Science and Engineering,Huazhong Univ
国内会议
宁波
英文
1003-1022
2014-11-11（万方平台首次上网日期，不代表论文的发表时间）