Antihypertensive evaluation of lignin related high-added-value 4-aryl-hexahydroquinolines

摘要：

　　4-Aryl-hexahydroquinolines prepared by Hantzsch reaction from aromatic aldehydes obtained from lignin had been proved to be excellent antioxidant property.In view of polyhydroquinoline containing similarities in structure to the biologically important compound,1,4-dihydropyridine,their antihypertensive activities were herein determined in spontaneously hypertensive rats (SHRs) during different time.The results show that those compounds possessing excellent antioxidant activity exhibit good antihypertensive property,and the compound containing syringyl moiety exhibit better antihypertensive activity than that containing guaiacyl moiety.This study suggests that those compounds may serve as promising agents for cure hypertension and free radical-related diseases.

关键词： Hexahydroquinoline Lignin Aromatic aldehyde Antihypertensive activity

作者: Xiao Hui Yang Guo Min Xiao Zhi Min Wang Yong Hong Zhou Guo Dong Feng

作者单位: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;Jiangsu Qi School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, China Jiangsu Qianglin Biomass Energy and Materials Co., Ltd.; Liyang 213364, China;Institute of Chemical

会议类型: 国际会议

会议名称: 2012 International Conference on Chemical Engineering,Metallurgical Engineering and Metallic Materials(2012化工、冶金和金属材料国际会议(CMMM2012))

会议地点: 昆明

会议语种:英文

页码: 7-10

在线出版日期: 2012-10-12（万方平台首次上网日期，不代表论文的发表时间）