Development of Planar Microelectrode Array for Extracellular Characterization of Action Potentials in Sinoatrial Node Cells
(0) In this research work we prototyped a planar microelectrode arrays that utilize SU-8 as the insulating material for non-invasive chronically characterization of action potentials from SA node cells. The microelectrode arrays are fabricated to form a microchannel based extracellular action potential characterization system which comprises a 2 by 50 linear microelectrode array for acquiring the action potentials with the principle of capacitive coupling and a full customized CMOS analog bio-signal readout ASIC for bio-signal conditioning and processing. The prototyped multi-channel mixed signal fully-customized CMOS biosensor analog front-end serves as the low magnitude action potential signal readout circuitry, which is comprised of analog signal buffers, high gain amplifier and control/interface. The concept of using epoxy-based photoresist SU-8 as the insulator instead of the conventional silicon nitride or silicon dioxide is due to the high insulation property and biocompatibility of the SU-8 material. This biocompatible planar microelectrode arrays with microchannels provides the biological scientists powerful tools for the long term non-invasive study of action potentials from SA node cells to screen libraries of chemical compounds for new drug candidates.
Xin Zhang Yulong Zhang Yingxin Li Richard D. Nelson John C. LaRue
Neural Engineering Research Lab, Z&L Creative Corporation, Lewes, DE 19958 USA and the Department of Pen-Tung Sah Micro-Nano Technology Research Center, Xiamen University, Fujian 361005 P. R. China Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140 USA Department of Electrical Engineering and Computer Science, University of California, Irvine, CA 9269 Mechanical and Aerospace Engineering Department, University of California, Irvine, CA 92697 USA
国际会议
2011 International Symposium on Bioelectronics and Bioinformatics(第二届国际生物医学电子学与生物信息学学术会议 ISBB 2011)
苏州
英文
1-4
2011-11-03（万方平台首次上网日期，不代表论文的发表时间）