Anti-tumor effect and its mechanism of Vaccaria segetalis on mouse inoculated H22 solid carcinoma
AIM Vaccaria segetalis was reported anti-tumor actionin vitro. In this study, the effect and mechanism of inhibiting tumorgrowth and improving the quality of life of Vaccaria segetalis onmouse inoculated H22 solid carcinoma were investigated.METHODS The solid carcinoma model of mouse was made byH22 cells subcutaneous injection and they were divided into fourgroups including model control group, 1mg/kg treatment dose,2.5mg/kg treatment dose and 5mg/kg treatment dose groups ofVaccaria segetalis.After ig treatment for 10 days,the mice werekilled,and the inhibited rate of tumor growing was calculated. Thepathological morhpologic change of tumor was observed by HEstaining.The apoptosis number of tumor was observed by TUNELmethod. The expression of CD31 of tumor endothelial cells wasmeasured by immunohistochemical method.RESULTS Vaccariasegetalis can improve the quality of life on mice invased by tumor,inhibite the growth of tumor.The effect of Vaccaria segetalis on thetumor morphology showed nuclear shrinkage, necrosis, andinflammatory cell infiltration on the periphery, etc. And it inhibitedthe expression of CD31, induced apoptosis of tumor cells andvascular endothelial cells.CONCLUSION Vaccaria segetalis can improve the the quality oflife on mice invased by tumor, and inhibit the growth of tumor. Themechanisms were likely due to inhibiting the angiogenesis, andinducing the apoptosis of tumor cells and vascular endothelial cells.
Yue-Ying GAO Li-Ying QIU Xiao-Xing KANG Hua Wang Ling-Yan Liu Lei FENG Jian JIN
School of medicine and pharmaceutics Jiangnan University Wuxi 214122, P.R.China
国际会议
成都
英文
1-4
2010-06-18（万方平台首次上网日期，不代表论文的发表时间）