Fabrication and Evaluation of Multi-layered Tubular Scaffold Based on Electrospun PCL-Gelatin/Chitosan Nanofibers
Introduction and Objective Electrospun fibers have been investigated as promising tissue engineering scaffolds since they mimic the nanoscale properties of native extracellular matrix (ECM). Fabrication of multilayered tubular scaffolds involves electrospun polycaprolactone (PCL) blended with a gelatin/chitosan complex (PCL-G/CS) as the inner layer in which electrospun nanofibrous scaffolds with high biostability can promote endothelial cells attachment and proliferation. For the outer layer, braiding poly(L-lactide) (PLLA) multifilaments with parallel yarns and large pore sizes can promote the growth of smooth muscle cells (SMCs) and improve the mechanical properties. Our research focused on the fabrication and evaluation of multi-layered tubular scaffolds. In particular we investigated the radial mechanical, fatigue resistance and compliance properties of multi-layered tubular scaffolds.
QIAN Yongfang KE Qinfeil Martin W.KING MO Xiumei
College of Textiles, Donghua University, Shanghai 201620, China Institute of Biological Science and College of Textiles, Donghua University, Shanghai 201620, China College of Textiles, Donghua University, Shanghai 201620, China College of Textiles, North Carolina Institute of Biological Science and Biotechnology, Donghua University, Shanghai 201620,China State K
国际会议
上海
英文
1348-1349
2009-05-27（万方平台首次上网日期，不代表论文的发表时间）