Electrospinning of Photosensitizer-loaded PLLA Nanofabrics for Anticancer Therapy
Photodynamic therapy (PDT) is a promising new treatment for cancer that has been recently accepted in the clinic. PDT is based on the administration of tumour-localizing photosensitizers (PSs), followed by the exposure of the neoplastic area to light absorbed by the PS. In this paper, a novel anticancer nanofabric membrance containing purpurin18 (0.1％) was successfully prepared. The thickness of membrane was 0.03 mm, and the average fiber diameter was 400 nm by scanning electron micrograph (SEM). It was indicated that PS purpurin-18 possessed excellent compatibility with PLLA from FT-IR spectrum. The physical properties of fabric membrane also were characterized by Differential Scanning Calorimetry (DSC) and X-ray diffraction (XRD).
purpurin-18 electrospinning anticancer nanofabric photodynamic therapy
DONG Sha YANG Xiao-xia CHEN Fen LI Yu-ling CHEN Zhi-long
Key Laboratory of Textile Science & Technology Ministry of Education, College of Textiles, Donghua U College of Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, P. R. China
国际会议
2010 International Forum on Biomedical Textile Materials(2010国际纺织生物医用论坛)
上海
英文
13-17
2010-05-28（万方平台首次上网日期，不代表论文的发表时间）