Common features identification of differently ezpressed genes related to endemic osteoarthritis disease
Kashin-Beck disease (KBD) is a chronic, endemic osteochondropathy in China. cDNA microarray techniques were used to select the differentially expressed genes between the healthy and KBD patients. 227 differently expressed genes were used to identify common characteristics. By using GeneMerge anaysis, the common functions of these genes were identified and some of which are related to metal ion binding, such as magnesium ion binding and zinc ion binding. The upstream sequences of these genes were also downloaded from genomic databases and a sequence dataset was constructed. A distance tree was then achieved according to sequences similarity comparing. Finally, 7 gene clusters, each of which contained 2～3 genes with similar function were obtained.
Kashin-Beck disease (KBD) microarray analysis gene ezpression regulation GO database
Xiaoming Wu Jianqiang Du Bo Wang Lili Liu Shuang Wang Xiong Guo
The Key Laboratory of Biomedical Information Engineering of Ministry of Education,Xian Jiaotong Uni Stomatological Hospital Xian Jiaotong University Xian 710049,China College Medicine,Xian Jiaotong University Xian 710049,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）