Preparation and evaluation of chitosan-coated alginate/gelatin sustained releasing microspheres containing berberine hydrochloride in vitro
The goal of this study was to evaluate the technological feasibility of delivering poorly water-soluble antibacterial agent using chitosan coated alginate/gelatin microspheres. The microspheres were prepared by an emulsification technique, characterized by Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM). Drug loading, encapsulation yield and release studies were also assessed according to the Chinese pharmacopoeia. The results implied that the microspheres were a useful dosage form to increase drug loading for the poorly watersoluble drugs by encapsulating with chitosan, indicated that they had satisfactory sustained releasing behavior in simulated gastric fluid.
berberine hydrochloride emulsification microsphere sustained releasing in vitro
Qiang-Song Wang Yuan-Lu Cui Ye Zhang Yan-Bin Zhang Xiu-Mei Gao
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Ministry of Education Tianjin Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique (Tianjin
国际会议
北京
英文
1-4
2009-06-11(万方平台首次上网日期,不代表论文的发表时间)