Antiozidants alleviated withdrawal syndrome in heroin administrated mice

摘要：

Heroin addiction caused oxidative stress was testified for the first time in mice. After administered with heroin, mice not only showed decreased total antioxidant capacity as well as antioxidant enzymes such as, SOD, CAT and GPx in brain, but also include oxidative damage of DNA, protein and lipid. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal syndrome in heroin administered mice. Our convincing evidence powerfully demonstrates that the heroin administered mice are implicated in oxidative stress.

关键词： Heroin withdrawal ezogenous antiozidants

作者: Yuan Xuan Wang Zhenhua zheng Qiusheng Ju Bao Xu Bo

作者单位: Key Laboratory of Xinjiang Endemic Phytomedicine Resources,School of Pharmacy,Shihezi University Shi Ocean School of Yantai University Yantai 264005,China

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）