Ozyresveratrol from Ramulus mori attenuates allozan-induced liver damage in mice
The protective effect of oxyresveratrol from Ramulus mori against alloxan induced liver damage in mice was examined. In this study, the activities of serum aspartate aminotransferase, serum alanine aminotransferase and superoxide dismutase, catalase and the contents of malonyldialdehyde and reduced glutathione in liver were measured. Mice were divided into five groups as control, model control (only treated with alloxan), alloxan + 25 mg/kg oxyresveratrol, alloxan + 50 mg/kg oxyresveratrol and alloxan + 30 mg/kg silymarin. The results revealed that alloxan could induce the liver damage through the elevation of transaminases activities and malondialdehyde accompanied by significant reductions in reduced glutathione level and superoxide dismutase and catalase activities. The treatment with oxyresveratrol can bring those changes to near normal level. The protective effect of oxyresveratrol was further supported by the histopathological observation and the expression of pro-inflammatory cytokines.
Ramulus mori allozan ozidative stress antiozidant enzyme mice
Zuo-fa Zhang Guo-ying Lv Lian-gen Shi Hui-juan Pan yong-zhi Wu Lei-fa Fan
Institute of Horticulture,Zhejiang Academy of Agricultural Science,Hangzhou 310021,China College of Animal Sciences,Zhejiang University,Hangzhou 310029,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）