Anti-inflammatory Activity of Salvianic acid A through the Inhibition of Nuclear Factor-κB Activation in Peritoneal Macrophage

摘要：

In the present study, we examined the anti-inflammatory properties of Salvianic acid A (SAA) in peritoneal macrophage induced by lipopolysaccharide (LPS). SAA inhibited the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in LPS-induced peritoneal macrophages and blocked protein expressions of inducible nitric oxide synthase (iNOS) and matrix metalloproteinase-9 (MMP-9). In addition, the LPS-induced nuclear factor-kappa B (NF-κB) activation was suppressed by SAA treatment.

关键词： Salvianic acid A (SAA) tumor necrosis factor-alpha (TNF-α) interleukin-6 (IL-6) inducible nitric ozide synthase (iNOS) matriz metalloproteinase-9 (MMP-9) nuclear factor-kappa B (NF-κB)

作者: Jun Yuan Ji-Hong Yao Qin Zhou Xiao-Wei Hu Liang Chu Xiao-Feng Tian

作者单位: Department of Pharmacology Dalian Medical University Dalian,116044,China Department of General Surgery Second Affiliated Hospital of Dalian Medical University Dalian,116023,

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-4

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）