4-Hydrozyphenylacetic Acid as a Monophenolase Inhibitor and a Diphenolase Activator on Mushroom Tyrosinase

摘要：

4-Hydroxyphenylacetic acid (4-HPA) can inhibit monophenolase (IC50=0.79 mM) and activate diphenolase of mushroom tyrosinase with its increasing concentrations. The activation kinetics, analyzed by Lineweaver-Burk plots, indicated 4-HPA to be a competitive and uncompetitive mixed-type activator of diphenolase when L-DOPA was used as substrate. 4-HPA can not only inhibit the oxy form but also activate the met form of mushroom tyrosinase.

关键词： 4-hydrozyphenylacetic acid mushroom tyrosinase monophenlase diphenolase inhibition activation

作者: Jian-Gang Xie Shu-Bai Li Yong Xue Hai-Tao Zhang Jing Quan Hua-Li Nie Li-Min Zhu Christopher Branford-Whiter

作者单位: College of Chemistry,Chemical Engineering and Biotechnology Donghua University Shanghai,China Depart College of Chemistry,Chemical Engineering and Biotechnology Donghua University Shanghai,China Institute for Health Research and Policy London Metropolitan University London,UK

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-3

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）