Inhibition action on Xantine Ozidase by biflavonoids from Selaginella labordei
Objective Xanthine oxidase inhibitory activities of the total biflavonoids and eight biflavonoid compounds isolated from the medicinal plants of Selaginella labordei have been investigated. Method The active compounds were screened out by measuring the inhibition rate and the 50％ inhibitory concentration (IC50) of each sample against xanthine oxidase (XOD) in vitro. Result Three kinds of biflavonoids were more active in inhibiting XOD than others, their inhibition rate was more than 85％ at the concentration of 10μg·mL-1.IC50 of the total biflavonoids, robustaflavone, 2,3-dihydro -3,3-biapigenin and 2,3-dihydroochnaflavone was 0.529, 0.162, 0.257, 0.254 μg·mL-1 respectively. Conclusion The three kinds of biflavonoids were active compounds in inhibiting XOD from Selaginella labordei, and the total flavonoids was the main active position.
Selaginella labordei biflavonoids zantine ozidase
LI Li CHEN Ke-li XU Jia-cheng LEI Xiang
Key Laboratory for Traditional Chinese Medicine Resource and Compound Prescription of Ministry of Ed Key Laboratory for Traditional Chinese Medicine Resource and Compound Prescription of Ministry of Ed
国际会议
北京
英文
1-3
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）