Synthesis and chareacterization of optically active macromolecular prodrugs with chemo-enzymatic protocol
A facile procedure combining enzymatic resolution with chemical polymerization was developed to prepare optically active polymeric prodrug containing glucose. Polymerizable optically active (R)-1-O-vinyladipoyl-chlorphenesin ((R)-OVAC) was obtained in excellent optically purity (ee>99.9％) and high yield (～50％) in short time, and optically active (S)-N-vinyladipoyl-propranolol ((S)-NVAP) was obtained in optically purity (ee=88％) by lipase-catalyzed resolution after optimization of reaction conditions. Then, polymerizable optically active monomer was copolymerized with polymerizable glycolipid 6-O-vinyladipyl-D-glucose (OVADG) using AIBN as the initiator. The obtained optically active polymeric prodrugs poly-(OVAC-co-OVADG) and poly-(NVAP-co-OVADG) were characterized by IR, NMR and GPC.
macromolecular prodrug enyzmatic resolution optically active polymerizable monomer glycolipid
Jing Quan Yan Zheng Cheng-Yao Wu Li-Min Zhu Xian-Fu Lin
College of Chemistry,Chemical Engineering and Biotechnology Donghua Universit,Shanghai,China Department of Chemistry Zhejiang University Hangzhou,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）