Effect of Medium Intensity Noise Ezposure on Emotional Learning and Memory of Young Mice
To study the effect of medium intensity noise exposure on emotional learning and memory of young mice and unravel its underlying mechanism, the emotional learning and memory were detected by step-down test and the contents of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were measured in this study. Kunming mice were divided into 2 groups (n=11 for each group): control group and noise group (were exposed to 80dB white noise for 2 hours every day and it lasted 7 days). The results showed that after 7 days exposure, the error times increased and step down latency decreased obviously in step-down test in noise group. As the indicators of oxidative stress, an increase of MDA contents and a decrease of SOD/MDA were found in noise group compared with control. The data suggested that the medium intensity noise exposure could reduce the ability of emotional learning and memory of young mice, which might involve the oxidative damage of hippocampus.
medium intensity noise young mice emotional learning and memory
Cheng Liang Qi Qiaozhen Tang Lili Wang Shaohui Liao Xiaomei Chen Qicai
Hubei Key Lab of Genetic Regulation ＆Integrative Biology College of Life Science,Central China Normal University Wuhan,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）