The Role of Excitatory and Inhibitory Synaptic Connectivity in the Pattern of Bursting Behavior in a Pyramidal Neuron Model
The connections between excitatory and inhibitory synapses ate significant for generation of busting activity in a pyramidal neuron model. We have suggested in previous studies that a reduced neuronal model of synaptically connected neurons could produce repetitive bursting activity. We have also suggested that the modification of the balance between inhibition and excitation by synaptic weight could alter the excitability of neuronal networks, In this computational study, we have investigated the role of the relative locations of excitatory and inhibitory synapses on the dendritic tree and soma in the generation of bursting activity. We have built a reduced pyramidal neuron model of synaptically connected neurons using the simulation software GENESIS. Our model consists of three reduced pyramidal neurons and an inhibitory intemeuron. Simulations show that a reduced pyramidal neuron model can accurately replicate bursting behavior. This bursting activity depends upon the synaptic parameters represented by synaptic weight and delay as well as the locations of synaptic inputs. Simulations with an intemeuron show that the inhibitory intemeuron regulates neuronal bursting activity. The inhibitory effect is stronger when the inhibitory synapse is close to the soma.
Pyramidal neuron model Inhibitory intemeuron Epileptiform activity
Keun-Hang Yang Piotr J. Franaszczuk Gregory K. Bergey
Department of Neurology, Johns Hopkins University School of Medicine and Johns Hopkins Epilepsy Center, Johns Hopkins Hospital, Meyer 2-147, Baltimore, MD
国际会议
8th International Conference on Neural Information Processing(ICONIP 2001)(第八届国际神经信息处理大会)
上海
英文
641-643
2001-11-14（万方平台首次上网日期，不代表论文的发表时间）