Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy
Diabetic nephropathy (DN) is a type of serious microangiopathy that is caused by diabetes mellitus (DM).It is the most common cause of chronic renal failure and end-stage renal disease, and it severely affects patients” quality of life.This work aims to study the effect and mechanism of low molecular weight fucoidan (LMWF) on streptozotocin (STZ)-induced DN.The experimental results showed that LMWF prevented weight loss in DN rats, significantly reduced the levels of biochemical indexes in blood and urine samples,and also lowered hyaluronic acid (HA) levels and advanced glycosylation end product-specific receptor (AGER) levels in DN rats.LMWF maintained the structural integrity of glomerular basement membrane (GBM) and glomerulus, improved the glomerular filtration function, protected glycosaminoglycan from abnormal degrading,prevented advanced glycosylation end product (AGE) from being generated and accumulating, and also alleviated inflammatory response in DN rats.LMWF could obviously ameliorate and slow the development and progression of DN in rats.
Fucoidan Diabetic nephropathy HSPG Glycosaminoglycan Inflammatory cytokines
Yingjie Xu Quanbin Zhang Dali Luo Jing Wang Delin Duan
Key Lab of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences,Qingdao Key Lab of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences,Qingdao Department of Pharmacology, School of Chemical Biology & Pharmaceutical SciencesCapital Medical Univ Key Lab of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences,Qingdao University of the Chinese Academy of Sciences,Beijing100049China;Lab for Marine Biology and Biotechn
国内会议
山东滨州
英文
103-119
2016-10-14（万方平台首次上网日期，不代表论文的发表时间）