Effect of Celecoxib plus standard chemotherapy on serum levels of VEGF and COX-2 in patients with gastric cancer
Objective Elevated serum levels of vascular endothelial growth factor(VEGF)and COX-2 are associated with poor prognosis in patients with gastric cancer.Little is known about the clinical benefit of combining Celecoxib,a selective inhibitor of cyclooxygenase 2(COX-2),with standard chemotherapy regimens for gastric cancer patients.In this study,we measured the effect of combinatorial use of Celecoxib with standard chemotherapy on the serum levels of VEGF and COX-2 in patients with gastric cancer.Methods 80 patients with gastric cancer underwent laparoscopic radical surgery were randomized to two groups: the combination group(Celecoxib plus standard chemotherapy FOLFOX4)(n=40),and FOLFOX4 alone group(n=40).In combination group,Celecoxib was given orally to the patients(400 mg,twice daily).Serum levels of VEGF and COX-2 were measured by ELISA before and after surgery.Results No significant difference in serum levels of VEGF and COX-2 was found between the combination group and FOLFOX4 alone group prior to chemotherapy(p>0.05).Following six cycles of chemotherapy,there was a greater decrease in the serum levels of VEGF and COX-2 in the combination group than in the FOLFOX4 group(p<0.01).In addition,the serum levels of VEGF and COX-2 were closely correlated in patients with gastric adenocarcinoma before treatment.Conclusion When combined with standard chemotherapy,Celecoxib could reduce the serum levels of VEGF and COX-2,implying that COX-2 inhibitor may have a therapeutic application through inhibition of tumor angiogenesis and prevention of recurrence or metastasis.Thus,Celecoxib may be a useful adjuvant agent to standard chemotherapy in patients with advanced gastric cancer.
Celecoxib,COX-2,vascular endothelial growth factor (VEGF),gastric cancer therapy
Hongtao Li Lin Su Xiaopeng Han Wankun Zhu Wei Xu Kun Li Qingchuan Zhao Hua Yang Hongbin Liu
Department of General Surgery,General Hospital of Lanzhou Military Region,＃333 Binhe South Road,Lanz Xijing Hospital of Digestive Disease,The Fourth Military Medical University,＃127 Changle West Road,X Xinqiao Hospital,The Third Military Medical University,＃183 Xinqiao Road,Chongqing 400037,China
国内会议
北京
英文
1-8
2017-05-19（万方平台首次上网日期，不代表论文的发表时间）