An elevated Systemic Immune-Inflammation Index(SII)is associated with a worse prognosis in patients with gastric cancer
Background Gastric cancer(GC)is the fifth most common form of carcinoma and the second leading cause of cancer-related mortality worldwide.Systemic immune inflammation index(SII)was report to be associated with prognosis in some malignant tumor.This study aimed to explore the association between SII and prognosis of gastric cancer.Methods We retrospectively analyzed data from 444 gastric cancer patients treated at the First Affiliated Hospital of Sun Yat-Sen University between 1994 and 2005.Preoperative SII was calculated using the data acquired before operation.The chi-square test was used to detect relationship between preoperative SII and clinicopathological characteristics.The impact of SII on overall survival(OS)was analyzed using Kaplan-Meier method and Cox proportional hazard models.Results High SII level indicated elder age(P = 0.002),larger tumor size(Χ2 = 20.867,P < 0.001),worse Borrmann classification(Χ2 = 10.079,P = 0.039),advanced tumor invasion(Χ2 = 23.504,P < 0.001),lymph node metastasis(Χ2 = 12.925,P = 0.005),distant metastasis(Χ2 = 36.571,P < 0.001),advanced Tumor-Node-Metastasis stage(Χ2 = 40.848,P < 0.001),higher CEA(Χ2 = 4.778,P = 0.029),NLR(Χ2 = 52.974,P < 0.001)and PLR(Χ2 = 86.897,P < 0.001)level.The elevated SII was significantly associated with a worse prognosis.Subgroup analysis further exhibited an significant association between high SII and poor OS.Conclusion The preoperative SII level is an independent prognostic factor for survival in gastric cancer.
Gastric cancer Preoperative SII Prognosis
Wang Kang Cai Shirong Chen Jianhui
Department of Gastrointestinal Surgery,The First Affiliated Hospital of Sun Yat-sen University,58 Zhongshan 2nd road,Guangzhou,510080,China
国内会议
北京
英文
1-13
2017-05-19(万方平台首次上网日期,不代表论文的发表时间)