Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy
Background Negative lymph node(NLN)count has been reported to provide more accurate prognostic information than the N stage alone in patients with rectal cancer(RC).Since preoperative radiotherapy(Pre-RT)can significantly affect the LN status,it is unclear whether NLN count still has prognostic value count on survival of patients with RC who received Pre-RT.Methods In this study,clinicopathological characteristics,number of positive LNs and survival time were collected from Surveillance,Epidemiology,and End Results Program(SEER)-registered RC patients.Univariate and multivariate Cox proportional hazards models were used to assess the risk factors for survival.Results X-tile plots identified 9(P < 0.001)as the optimal cutoff NLN value to divide the patients into high and low risk subsets in terms of cause specific survival(CSS).NLN count was validated as independently prognostic factor in univariate and multivariate analysis(P < 0.001).Subgroup analysis showed that NLN count was an independently prognostic factor for patients with stage ypⅡ(P = 0.002)and ypⅢ(P < 0.001).Conclusions Our results firmly demonstrated that NLN count provides accurate prognostic information for RC patients with Pre-RT.
Rectal cancer preoperative radiotherapy negative lymph node survival
XinxingLi Hao Lu Kai Xu Haolu Wang Xiaowen Liang Zhiqian Hu
Department of General Surgery,Changzheng Hospital,the Second Military Medical University,415 S.Fengy Therapeutics Research Centre,School of Medicine,The University of Queensland,Princess Alexandra Hosp
国内会议
北京
英文
1-19
2017-05-19(万方平台首次上网日期,不代表论文的发表时间)