Clinicopathological significance of c-MYC in esophageal squamous cell carcinoma
Aim: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors.The oncogene c-MYC is thought to be important in the initiation, promotion, and therapy resistance of cancer.In the present study, the aim of this study was to investigate the clinicopathologic roles of c-MYC in ESCC tissue.Methods: Present study is aimed at discovering and analyzing c-MYC expression in a series of human esophageal tissues.95 ESCC samples were analyzed by the WB and IHC techniques.Then, correlation of c-MYC expression with clinicopathological features of ESCC patients was statistically analyzed.Results: Compared with normal and atypical hyperplasia tissues, c-MYC was higher expressed in esophageal cancer tissue.In most ESCC cases, the c-MYC expression was positive in tumor tissues, The PR (positive rate) of c-MYC expression in tumor tissues was 66.32% (63/95), obviously higher than the adjacent normal tissues (ANT) (4.21%, 4/92) and Atypical hyperplasia tissues (25.26%, 24/95).There was a statistical difference among ANT, Atypical hyperplasia tissues and tumor tissues.Over-expression of the c-MYC was detected in 66.32% (63 of 95) ESCCs, which was significantly correlated with the degree of differentiation (P =0.000).The PR of c-MYC expression was 40.0% (6/15) in well differentiated esophageal tissues, and 41.4% (24/58) in moderate differentiated esophageal tissues, but only 90.9% (20/22) in poor differentiated tissues, with a significantly statistical difference (P =0.000).The PR of c-MYC was 41.5% (17/41) in T1+T2 esophageal tissues, and 87.0% (47/54) in T3+T4 esophageal tissues, with a significantly statistical difference (P =0.000).The PR of c-MYC was 30.0% (12/40) in Ⅰ +Ⅱ esophageal tissues, and 89.1% (49/55) in Ⅲ+Ⅳ esophageal tissues, with a significantly statistical difference (P =0.000).The PR of c-MYC was 86.8% (46/53) in T1+T2 esophageal tissues, and 40.5% (17/42) in T3+T4 esophageal tissues, with a significantly statistical difference either (P =0.000).The C-MYC expression strongly correlated with clinical staging (P=0.000), differentiation degree (P=0.000), lymph node metastasis (P=0.000) and invasion depth (P=0.000) of patients with ESCC.Conclusion: The c-MYC was differentially expressed in a series of human esophageal tissues, and the aberrant c-MYC expression could be a potential factor in carcinogenesis and progression of ESCC.There was a statistical signification for c-MYC in ESCC patients to analyze clinicopathological features.It possibly become a new diagnostic indicators of ESCC.
Esophageal squamous cell carcinoma c-MYC Western blot clinicopathology immunohistochemistry
Xiangdong Niu Hui Cai Xiaojun Yang Haizhong Ma Shixun Ma Yupeng Zhang Yifeng Chen
General surgery clinical center of Gansu province, Lanzhou, 730000, China
国内会议
兰州
英文
560-568
2016-10-01（万方平台首次上网日期，不代表论文的发表时间）