Nanosuspensions based nanogel as delivery system for nitrofurazone for dermal application
Objective: The present investigation aimed for the development and evaluated of nanosuspensions-based hydrogel formulations of nitrofurazone(NTZ)for enhanced topical delivery.Methods: NTZ nanosuspension(NTZ-NS)was fabricated by wet media milling technique.Box–Behnken design was implemented to study the influence of bead volume,milling time,polymer and surfactant concentrations on particle size(PS),polydispersity index(PDI)and stability(stability index,SI).The optimized NTZ-NS was subsequently incorporated into Carbopol 940 gel and evaluated for particle size distribution,drug content,spreadability,pH,scanning electron microscopy(SEM),X-ray diffraction(XRD),in vitro release,in vitro permeation and stability.Results: The particle size analysis and SEM studies revealed NTZ nanosuspensions was still stably kept their particle size after suitably gelled by carbopol preparation.The drug content,pH and spreadability of the GLT nanogel was found to be 98.63 ± 2.2%,6.27 ± 0.20 and 25.74(g·cm)/s,which were within acceptable limits.XRPD studies suggested slight crystalline change in drug.Dissolution rate obtained from NTZ nanogel were markedly higher than NTZ-carbopol-gel.In vitro permeation studies through rat skin indicated that the amount of NTZ permeated through skin of NTZ nanogel after 24 hours was higher than NTZ-carbopol-gel,and NTZ nanogel increased the accumulative amount of NTZ in epidermis 4.5 times than NTZ-carbopol-gel.Conclusion:.These results suggested that the developed nanogel had a great potential as a viable approach to enhance the dermal bioavailability of NTZ
Nanosuspensions media milling nanogel nitrofurazone dermal application
Chengying Shen Baode Shen Xiao Liu Yan Wu Fucheng Zhang Hailong Yuan
Department of Pharmacy,Air Force General Hospital,PLA,Beijing 100142,China
国内会议
北京
英文
1-24
2016-12-16（万方平台首次上网日期，不代表论文的发表时间）