Genistein improves glucose control and insulin sensitivity in postmenopausal women:A meta-analysis

摘要：

　　Objective The results of randomized controlled trials(RCTs)assessing effects of genistein on glucose metabolism are inconsistent.The aim of this meta-analysis is to evaluate the effects of genistein on glucose control and insulin sensitivity in postmenopausal women.Methods We searched Medline,PubMed,Cochrane databases,and ClinicalTrials.gov for trials from January 1970 to February 2016.RCTs that investigated the effects of genistein on glucose and insulin metabolism in postmenopausal women were included.We performed pooled analyses with weighted mean difference(WMD)and 95%confidence interval(CI)according to the RevMan 5.3 software with the random-effects model.Results Seven eligible RCTs with 670 participants were included in the meta-analysis.Compared to placebos,genistein exhibited significant effects in lowering fasting glucose levels(WMD,-6.35 mg/dL ”95%CI,-10.78 to-1.93”; P = 0.005),fasting insulin concentrations(WMD,-1.92 μIU/mL ”95%CI,-3.04 to-0.79”; P = 0.0008),and HOMA-IR values(WMD,-0.74 ”95%CI,-1.21 to-0.28”; P = 0.002).Conclusions Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women.Long-term genistein treatment may exert more significant effects than short-term use.

关键词： genistein glucose metabolism insulin sensitivity postmenopausal meta-analysis

作者: Yang Liu Jiapeng Li Tiansheng Wang Yitong Wang Libo Zhao Yi Fang

作者单位: Department of Pharmacy,Peking University People”s Hospital,11 Xizhimen South Street,Xicheng District Department of Pharmacy Administration and Clinical Pharmacy,School of Pharmaceutical Sciences,Peking Department of Pharmacy,Beijing Children”s Hospital,Capital Medical University,56 Nanlishi Road,Xiche Department of Pharmacy,Peking University People”s Hospital,11 Xizhimen South Street,Xicheng District

会议类型: 国内会议

会议名称: 2016年北京药学年会

会议地点: 北京

会议语种:英文

页码: 1-25

在线出版日期: 2016-12-16（万方平台首次上网日期，不代表论文的发表时间）