Myocardium-targeted transplantation of PHD2 shRNA-modified mesenchymal stem cells by ultrasound-targeted cationic microbubble destruction improves cardiac function in myocardial infarction of rats

摘要：

Objective:Mesenchymal stem cell therapy has been proposed as a promising therapy for acute myocardial infarction(AMI).However,some studies showed little effect of MSCs on AMI.One of the limitations are low homing efficiency of MSCs at the site of injury.We hypothesis that Ultrasound targeted microbubble destruction(UTMD) technique combined with PHD2shRNA-modified MSCs enhances the homing efficiency of transplanted stem cells and improves cardiac function in myocardial infarction of rats.

作者: Li Zhang Zhengxing Sun MingxingXie

作者单位: Department of Ultrasound,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology Hubei Provincial Key Laboratory of Molecular Imaging,Wuhan 430022,China

会议类型: 国内会议

会议名称: 2018海峡两岸医药卫生交流与合作会议暨第十届海峡两岸超声医学高端论坛

会议地点: 厦门

会议语种:英文

页码: 1188-1190

在线出版日期: 2018-05-04（万方平台首次上网日期，不代表论文的发表时间）