Cell cycle re-entry relates to neuronal apoptosis after exposure to benzo”a”pvrene in SD rats
As a widely distributed environmental contaminant, B”a”P could cause neuronal cell apoptosis in animal models.Several studies have indicated that cell cycle re-enter plays a major role in neuronal apoptosis.Currently, a study was undertaken to investigate cell cycle re-entry in neuronal apoptosis after exposing to B”a”P in SD rats.Male SD rats were administrated with B”a”P by intraperitoneal injection at different dose (blank, 0, 1.0, 2.5, 6.25 mg/kg bw) for 1, 2, and 3 months.Neuronal apoptotic rate of hippocampus was significantly increased in a dose and time dependent manner.To find the relationship between neuronal apoptosis and cell cycle re-entry, the cyclinD1, CDK4, Rb, pRb-ser 807/811, pRb-ser 780 and E2F1 were measured, which are related with cell cycle re-entry.Rb, pRb-ser 807/811,pRb-ser 780 and E2F1 increased in a dose and time dependent manner in hippocampus, The present results suggest that the cell cycle re-enter relates to neuronal apoptosis following exposure to B”a”P in SD rats, implying that B”a”P may be related to neurodegenerative diseases.
Benzo”a”pyrene neuronal apoptosis cell cycle re-entry
NIE Jisheng YAN Zhiwei DUAN Lei TANG Deliang NIU Qiao
Department of Occupational Health, School of Public Health, Shanxi Medical University,Taiyuan, Shanx Department of Occupational Health, School of Public Health, Shanxi Medical University,Taiyuan, Shanx Department of Environmental Health Sciences and Columbia Center for Children”s Environmental Health,
国内会议
河南开封
英文
9-19
2016-11-01（万方平台首次上网日期，不代表论文的发表时间）